Glass Microfiber Pharmaceutical Prefilters - PROCLEAR PG

PROCLEAR GF glass microfiber pharmaceutical liquid prefilters provide reliable, cost‑effective clarification and prefiltration of pharmaceutical liquids. These pleated depth filters combine high‑capacity glass microfiber (microfibre) media with robust polypropylene hardware to deliver efficient removal of particulate and microorganisms before final sterilizing‑grade membranes.

The non‑fiber‑releasing glass microfiber media offers excellent dirt‑holding capacity and high flow rates, enabling longer service life, fewer changeouts, and more compact filtration systems. Pleated construction maximizes effective filtration area while maintaining low differential pressure, making PROCLEAR GF an economical choice for prefiltration duties in buffer preparation, media filtration, and bulk drug substance processing.

PROCLEAR GF filters are available as full‑size cartridges, demi cartridges, MURUS single‑use capsules, DEMICAP capsules, and 50 mm syringe filters, allowing seamless scale‑up from lab to pilot to production. A wide range of micron ratings (0.6–10 µm), lengths, end configurations, and connection options simplifies integration into existing pharmaceutical filtration trains.

Manufactured to pharmaceutical‑grade standards, PROCLEAR GF filters feature low extractables, low endotoxin contribution, and materials that comply with FDA 21 CFR 177, USP Class VI plastics at 121 °C, and ISO 10993 equivalents. They meet current USP purified water requirements for TOC, conductivity, and oxidizable substances after defined flushing, and can be hot‑water sanitized, autoclaved, or gamma‑irradiated (capsules) to support stringent cGMP environments.

Key Features

• Non‑fiber‑releasing glass microfiber depth media for reliable clarification
• High dirt‑holding capacity for long service life and maximum throughput
• Pleated construction for high flow rates and low pressure drop
• Broad micron range from 0.6 to 10 µm for staged prefiltration design
• Multiple formats: cartridges, demi cartridges, MURUS and DEMICAP capsules, syringe filters
• Single‑use capsule options that can be gamma‑irradiated and autoclaved
• Low extractables and low endotoxin contribution to protect critical products
• Materials compliant with FDA 21 CFR 177, USP Class VI, and ISO 10993 equivalents
• Compatible with hot‑water sanitization, SIP, and common CIP chemicals
• Standard Tri‑Clamp, hose barb, NPT, and Luer connections for easy integration

Typical Applications

PROCLEAR GF glass microfiber pharmaceutical liquid prefilters are typically used for:

• Clarification and prefiltration of pharmaceutical solutions and process intermediates
• Prefiltration upstream of sterilizing‑grade membrane filters in biopharmaceutical processes
• Particle and bioburden reduction in buffer and media preparation
• Prefiltration of purified water and WFI used in manufacturing (within stated operating limits)
• Scale‑up, pilot, and laboratory filtration with DEMICAP capsules and syringe filters

Note: PROCLEAR and DEMICAP are registered trademarks of Parker Hannifin Corporation