Product Description
PROCLEAR PP polypropylene pharmaceutical prefilters provide robust, high-capacity clarification for a wide range of drug product, intermediate, and utility liquids. These pleated, all-polypropylene filters are engineered as pharmaceutical liquid prefilter cartridges to protect downstream sterilizing-grade membranes and critical unit operations while maintaining excellent chemical compatibility.
Using graded-density polypropylene media and an optimized pleat design, PROCLEAR PP elements deliver high throughput to blockage and long service life, even in demanding clarification and prefiltration duties. The rigid all-polypropylene construction resists deformation under differential pressure and aggressive CIP conditions, helping to maintain consistent performance over multiple cycles.
PROCLEAR PP pharmaceutical prefilters are available in micron ratings from fine clarification through coarse particulate removal and in standard 2.5″ to 40″ cartridge lengths, as well as MURUS and DEMICAP capsule formats and syringe filters. This broad configuration range allows easy integration into existing pharmaceutical housings and single-use assemblies for both small-scale development work and full-scale production.
Manufactured under cGMP conditions and flushed with pharmaceutical-grade purified water, PROCLEAR PP filters feature low extractables and low endotoxin levels. Materials of construction comply with FDA 21 CFR Part 177 and USP Class VI requirements, supporting use in biopharmaceutical, vaccine, and sterile API processes where product quality and regulatory compliance are critical.
Key Features
- Pleated polypropylene pharmaceutical liquid prefilter design for high-efficiency clarification
- Graded-density polypropylene media for high dirt-holding capacity and long service life
- All-polypropylene wetted construction for broad chemical compatibility
- Wide micron range for coarse to fine prefiltration of pharmaceutical liquids
- Available as cartridges, disposable capsules (MURUS, DEMICAP), demi cartridges, and syringe filters
- Low extractables and low endotoxin levels to protect sensitive drug products
- Compatible with hot-water sanitation, SIP, and common CIP chemistries
- Manufactured under cGMP with pharmaceutical-grade water flushing
- Multiple end-cap and connection options for easy retrofit into existing systems
Typical Applications
PROCLEAR PP polypropylene pharmaceutical prefilters are used for clarification and prefiltration of:
- Biopharmaceutical products and intermediates
- Vaccines, recombinant proteins, and therapeutic biologics
- Buffer solutions, process water, and WFI prefiltration
- Cell culture media and serum-containing feeds (as a prefilter)
- Final polishing and bioburden reduction prefiltration upstream of sterilizing-grade PES membranes
- Filtration of aggressive or solvent-containing process streams where all-polypropylene construction is preferred
Note: PROCLEAR and DEMICAP are registered trademarks of Parker Hannifin Corporation
Specifications
| Filter Type | Pleated |
|---|---|
| Micron Ratings | 0.6 µm, 1.0 µm, 3.0 µm, 5.0 µm, 7.0 µm, 10.0 µm, 15.0 µm, 20.0 µm, 25.0 µm, 40.0 µm, 55.0 µm, 75.0 µm, 100.0 µm |
| Cartridge Lengths | 2.5", 5", 10", 20", 30", 40" |
| Effective Filtration Area | Up to approx. 0.79 m² (8.5 ft²) per 10" (250 mm) cartridge |