SciLog^® Filter & Dispense Bag System

Parker’s SciLog^® Filter & Dispense Bag System is an automated bulk filtration and dispense platform designed to standardize aseptic bag filling operations for biopharmaceutical processes. This single-use system combines bulk filtration, in-line filter integrity testing, and gravimetric dispensing into one compact skid, providing consistent, repeatable performance for bulk drug substance (BDS) and other high-value fluids.

Using a closed flow path with sterile single-use manifolds and DuraPure bags, the SciLog Filter & Dispense Bag System minimizes operator intervention and environmental exposure while accurately filling up to twelve 1–20 L bags per manifold. Integrated automation manages air removal, filter flushing and conditioning, pre- and post-use integrity testing, and gravimetric dispense control to reduce variation and improve overall process robustness.

The system incorporates a Quattroflow single-use pump for filtration and a Watson Marlow or Masterflex peristaltic pump for dispensing, delivering controlled flow rates suitable for a range of bioprocessing applications. Programmable alarms and interlocks, 21 CFR Part 11-compliant SciSoft software, and plant integration via OPC, Profibus, or Ethernet IP support GMP environments and electronic batch record strategies.

Single-use manifolds constructed from platinum-cured silicone, polypropylene, polysulfone, Pharmapure TPE, and polycarbonate are supplied with full documentation, including system and manifold certificates of compliance and gamma irradiation certificates. With a compact 73 in x 36 in x 75 in footprint, ergonomic bag trays, and 99% product recovery from the dispensing spine, the SciLog Filter & Dispense Bag System helps life science manufacturers increase yield, reduce changeover time, and streamline BDS bulk fill operations.

Key Features

• Automated bulk filtration and aseptic bag filling for BDS and other high-value bioprocess fluids
• Simultaneous filtration and dispensing with integrated pre- and post-use filter integrity testing
• Closed, single-use flow path with sterile connections to reduce contamination risk and environmental monitoring needs
• Fills up to twelve 1–20 L single-use bags accurately and reproducibly per manifold
• Programmable recipes for flushing, equilibration, integrity testing, filtration, dispensing, and recovery
• High product recovery with automated reverse flow and purge functionality (up to 99% recovery in dispensing spine)
• Ergonomic design with removable bag trays and aseptic disconnections for fast changeovers
• SciSoft control software with 21 CFR Part 11-compliant data handling and electronic records
• PLC-based automation with fully configurable alarms and interlocks to protect operator, product, and process
• Integration to plant control systems via OPC, Profibus, or Ethernet IP for GMP manufacturing environments

Typical Applications

The SciLog Filter & Dispense Bag System is ideal for:

• Bulk drug substance (BDS) filtration and aseptic bulk bag fill
• Final bulk fill of vaccines, monoclonal antibodies, and other biologics to single-use bags
• Sterile filtration and dispensing of buffers, media, and intermediates into 1–20 L bags
• Single-use bioprocessing suites in biopharmaceutical and biotech manufacturing facilities
• Contract manufacturing and fill-finish operations requiring standardized, automated bulk fill