SciLog^® TFF Standard Tangential Flow Filtration System

Parker’s SciLog^® TFF Standard, a fully automated tangential flow filtration (TFF) system designed for GMP bioprocessing. This pre-configured, single-use TFF platform delivers reliable, repeatable performance across a defined range of process specifications, making it ideal for production-scale ultrafiltration and microfiltration operations that demand robust automation and data integrity.

The SciLog TFF Standard system combines a compact footprint with intelligently engineered single-use manifolds to minimize hold-up volume and maximize product yield. It can utilize virtually any brand of TFF cassette or hollow fiber module in either single-use or reusable format, allowing you to standardize on your preferred membranes while benefiting from advanced process control and automation.

With integrated single-use pressure and conductivity sensors, recipe-based control, and a touch-screen HMI, the SciLog TFF Standard automates key process parameters such as feed, permeate, and recirculation flow, as well as diafiltration steps. The system is 21 CFR Part 11 ready and designed for straightforward integration into DCS/SCADA environments, supporting electronic records, user access control, and automated data capture for GMP compliance.

Available in low, medium, and high-flow configurations, the SciLog TFF Standard covers feed flow ranges from development through commercial scale. Its standardized turnover package – including system manuals, P&IDs, electrical schematics, and calibration certificates – helps engineering, validation, and QA teams bring new systems online faster while maintaining the documentation traceability expected in regulated life science manufacturing.

Key Features

• Fully automated tangential flow filtration system for GMP bioprocessing
• Single-use manifolds designed to minimize hold-up volume and product loss
• Supports ultrafiltration and microfiltration with integrated diafiltration capability
• Compatible with a wide range of cassette and hollow fiber TFF formats
• Recirculation flow capacity up to approximately 83 L/min depending on model
• Operating pressure up to 60 psi for UF/MF applications
• Recipe-based control for discrete steps or batch-mode processing
• Touch-screen HMI with intuitive graphical interface
• 21 CFR Part 11 ready control platform with user access level management
• Easy integration with plant DCS/SCADA systems via common industrial protocols
• Compact footprint TFF skid with standardized documentation and qualification support

Typical Applications

The SciLog TFF Standard is designed for automated TFF steps in regulated bioprocessing environments, including:

• Concentration and diafiltration steps in biopharmaceutical manufacturing
• Ultrafiltration and microfiltration of process intermediates and bulk drug substances
• Single-use TFF operations in clinical and commercial GMP suites
• Pilot and production-scale life science applications requiring automated, recipe-driven TFF
• Integration with upstream and downstream unit operations via plant DCS/SCADA