Sterilizing Grade Mycoplasma Removal Filters - PROPOR MR

PROPOR MR sterilizing grade filters are engineered specifically for fast, reliable mycoplasma removal from pharmaceutical cell culture media. These pleated 0.1 micron PES elements provide validated mycoplasma control while maintaining high flow rates, making them an excellent choice when you need a robust mycoplasma removal filter cartridge or capsule that will not bottleneck upstream processing.

At the heart of PROPOR MR is a highly retentive polyethersulfone (PES) membrane with an integral asymmetric prefilter layer. This dual-layer design combines high capacity, low pressure drop, and long service life, allowing you to condense filter trains and reduce overall filtration footprint. The membrane is fully validated as sterilizing grade by bacterial challenge testing and demonstrates typical log reduction values greater than 10 for Acholeplasma laidlawii, providing strong assurance of mycoplasma control in critical bioprocessing steps.

PROPOR MR filters are offered as full-size cartridges, demi cartridges, and single-use MURUS and DEMICAP capsules, as well as syringe formats for small-volume work. Standard cartridge lengths from 5 in to 40 in integrate into common sanitary housings, while capsule options with Tri-Clamp, hose barb, and NPT connections support flexible, single-use or lab-scale setups. All configurations use high-purity polymeric materials with low extractables and low endotoxin release, and can be sanitized with hot water or autoclaved/SIP’d according to Parker’s guidelines.

Designed for use in the biopharmaceutical industry, PROPOR MR filters are ideal for mycoplasma removal from cell culture media and feeds, as well as sterilizing grade filtration of associated buffers and process intermediates. CLEAR Solutions backs these elements with deep process filtration experience and application support, helping you select and size PROPOR MR filters that improve process safety while managing total cost of ownership.

Key Features

• Sterilizing grade 0.1 micron PES membrane for mycoplasma removal from cell culture media
• Validated bacterial retention and typical LRV >10 for Acholeplasma laidlawii
• Integral asymmetric prefilter layer for high dirt-holding capacity and extended throughput
• High flow rates to minimize batch processing times and filtration bottlenecks
• Low extractables and low endotoxin release to support stringent biopharmaceutical requirements
• Available as cartridges, demi cartridges, MURUS and DEMICAP single-use capsules, and syringe filters
• Broad range of sanitary and hose barb connections for easy integration into existing skids and single-use assemblies
• Compatible with hot water sanitization, SIP/autoclave, and gamma irradiation (capsules) as specified by Parker
• Materials compliant with key biopharmaceutical standards (FDA 21 CFR Part 177, USP Class VI, ISO 10993 equivalents)

Typical Applications

Suitable for critical upstream and media-related biopharmaceutical duties, including:

• Mycoplasma removal from mammalian cell culture media and feeds
• Final filtration of media prior to bioreactor inoculation
• Sterilizing grade filtration of buffers and process intermediates associated with cell culture operations
• Mycoplasma control and sterilizing grade filtration in monoclonal antibody, recombinant protein, and other biologics production
• Lab-scale and pilot-scale media preparation using single-use DEMICAP and MURUS capsules

Note: PROPOR and DEMICAP are registered trademarks of Parker Hannifin Corporation